Didactics-Adjuvant Treatment for Endometrial Cancer-Current Practice and Molecular Classificationn

Adjuvant Treatment for Endometrial Cancer-Current Practice and Molecular Classificationn - Part 1

Video Transcription

Video Summary

In this video, the speaker provides a brief summary of adjuvant treatment for endometrial cancer. They mention that the majority of women with a new diagnosis of endometrial cancer are diagnosed at an early stage and have favorable prognosis. Surgery with lymphadenectomy is the primary treatment, but sentinel lymph node dissection is becoming an alternative. Adjuvant treatment is based on clinical and pathological factors such as age, grade, histological type, myometrial invasion, and lymphovascular space invasion. Low-risk patients with endometrial cancer usually do not require adjuvant treatment. High-intermediate-risk patients may receive external beam radiation therapy or vaginal brachytherapy. The treatment for high-risk patients is less established, but options include pelvic radiation plus brachytherapy boost or chemotherapy with vaginal brachytherapy. For stage three patients, combination chemotherapy and radiation therapy is recommended, although the sequence is still debated. Treatment for non-endometrial histologies such as serous, clear cell, and carcinosarcoma usually involves chemotherapy, with the addition of external beam radiation therapy for stages above 1B.

Asset Subtitle

Shira Felder
November 2020

Keywords

adjuvant treatment

endometrial cancer

lymphadenectomy

chemotherapy

radiation therapy