Didactics-Advanced Vulvar Cancer

Video Transcription

Video Summary

The lecture addresses the management of advanced vulvar cancer at the University of Maryland. It covers the disease's epidemiology, pathophysiology, and common histological types like squamous cell carcinoma, often associated with HPV, and melanoma. The speaker highlights two interesting cases of advanced vulvar cancer, emphasizing multidisciplinary treatment approaches including surgery, radiation, and systemic therapies like immunotherapy. Discussing treatments, the lecture mentions the use of Pembrolizumab, an immunotherapy drug, and its rare side effects such as neuropathy. The challenges in treating immunosuppressed patients, particularly those with HIV, are noted, as studies indicate a higher risk and earlier presentation of vulvar cancer in these populations. Additionally, the speaker highlights the importance of assessing lymph node involvement and mentions the limited access to radiation therapy globally. Surveillance guidelines are provided, stressing frequent monitoring for advanced-stage patients to manage the substantial morbidity associated with vulvar cancer.

Asset Subtitle

Dana Roque
December 2024

Keywords

advanced vulvar cancer

multidisciplinary treatment

immunotherapy

Pembrolizumab

lymph node involvement

HIV