Didactics-Emerging Developments and New Concepts in Gynaecological Pathology_ Gustavo Focchi

Emerging Developments and New Concepts in Gynaecological Pathology_ Gustavo Focchi_ April 2020

Video Transcription

Video Summary

In this video, the speaker discusses advances in the pathology of squamous cell carcinoma of the vulva and its precursors. They highlight the recognition of intrapathy-like lesions that simulate differentiated vulvar intraepithelial neoplasia (DVIN) and sclerosis-like lesions but are actually related to HPV. The speaker shares findings from a study examining HPV-positive tumors and verifies the association with HPV through positivity for B16 and RNA. They also discuss various subtypes of vulvar squamous cell carcinoma, including HPV-positive with B53 wild-type, HPV-negative with B53 abnormal, and HPV-negative with frequent NOTCH1 mutations. The local recurrence rates differ among these subtypes. The speaker emphasizes the importance of routinely reporting HPV status in vulvar squamous cell carcinoma and highlights the prognostic value of P16 and P53 immunohistochemistry. They also discuss perineural invasion and methods for measuring depth of invasion. The video concludes by discussing PD-L1 suppression and activated helper T cells as favorable prognostic factors in vulvar squamous cell carcinoma.

Keywords

squamous cell carcinoma

vulva

HPV

subtypes

recurrence rates

prognostic factors