Didactics-Gestational Trophoblatic Diesease

Video Transcription

Video Summary

The video is a lecture on gestational trophoblastic disease (GTD) given by Dr. Alex Olawe at the University of Pittsburgh. The objectives of the discussion are to understand the etiology of GTD, recent surgical therapy alterations, medical management for low and high-risk disease, and the role of immune checkpoint inhibition. Dr. Olawe provides an overview of placenta embryology, categorizing the chorionic villi into primary, secondary, and tertiary types. He explains that GTD includes all abnormalities related to placental trophoblast, which are not all malignant. He goes on to discuss molar pregnancies, including complete and partial moles, their diagnosis, pathology, and treatment options. He explains that complete moles are diploid and partial moles are triploid. He also covers the diagnosis and treatment of gestational trophoblastic neoplasia (GTN), the malignant component of GTD. He discusses different chemotherapy regimens for both low and high-risk GTN, including methotrexate, actinomycin D, and combination therapies like Emaco and MIEP. Dr. Olawe also addresses the use of immune checkpoint inhibitors, such as pembrolizumab and avelumab, in refractory GTN cases. He concludes by highlighting the positive outcomes for future pregnancies in GTD patients and the potential of immune therapies for treating the disease.

Asset Subtitle

Alex Olawaiye
December 2022

Keywords

gestational trophoblastic disease

etiology

medical management

molar pregnancies

diagnosis

treatment options

gestational trophoblastic neoplasia

chemotherapy regimens

immune therapies