Didactics-Gyn Malignancies_Parp Inhibitors_John Chan Vietnam Feb 2022.mp4

Gyn Malignancies_Parp Inhibitors_John Chan Vietnam Feb 2022.mp4

Video Transcription

Video Summary

In this video, the speaker discusses new treatments for ovarian cancer, focusing on the role of genomic instability in cancer cells. They explain how DNA repair mechanisms can be exploited to develop drugs that inhibit PARP enzymes, leading to double-stranded breaks in the DNA and cell death. The speaker highlights the significant benefits of PARP inhibitors in treating ovarian cancer, particularly in patients with BRCA gene mutations. They also discuss the potential benefits in non-BRCA patients and the possibility of combining PARP inhibitors with other therapies. The speaker concludes by expressing gratitude to colleagues and sharing personal experiences from Vietnam.

Keywords

ovarian cancer

genomic instability

DNA repair mechanisms

PARP inhibitors

BRCA gene mutations