Didactics-High Risk GTN

Video Transcription

Video Summary

In this video, the speaker discusses the management of high-risk gestational trophoblastic neoplasia (GTN). The speaker explains that GTN has both benign and neoplastic components, with the high-risk types being invasive mole and choriocarcinoma. Staging is done using the FIGO system, and risk assessment is done using the WHO scoring system. High-risk GTN is defined as invasive mole or choriocarcinoma, FIGO stage 4, or FIGO stage 2-3 with a WHO score greater than 6 or 7. Treatment options include single-agent chemotherapy for lower-risk cases, and multi-agent chemotherapy for higher-risk cases. The speaker also discusses induction chemotherapy and different treatment regimens. A case presentation is shared, highlighting the challenges and outcomes of high-risk GTN treatment. The importance of monitoring for tumor lysis syndrome and considering radiation therapy is also mentioned. Lastly, the use of the V-CAP SOs prognostic scoring system for recurrent GTN is discussed.

Asset Subtitle

Joseph Lucci III
January 2024

Keywords

gestational trophoblastic neoplasia

high-risk GTN

chemotherapy

FIGO staging

tumor lysis syndrome