of cancer elimination in countries by 2030. We all know that cervical cancer is a reventable disease. However, until now, it's still the fourth most common cancer among women globally, with an estimated 600,000 new cases and more than 400,000 deaths in 2030. That's why the WHO called for action to eliminate cervical cancer in the world. And this is the most famous target in the world, 90-70-90 target to be met by all countries by 2030. It means we have to achieve at least 90% of neuros fully vaccinated with HPV vaccine by age 15 years, and 70% of women are screened with high-performance tests by 35 years of age, and 90% of women identified with cervical disease receive a treatment. But look at the reality. We know that about 90% of new cases and deaths of cervical cancer occurs in low- and middle-income countries. And in Vietnam, we had more than 4,000 new cases and 2,200 deaths of cervical cancer in 2020. And in Chiang Nang, according to CDC data, the cervical cancer screening rate in the target group only 30% in 2022. So we have the different starting points in the world, but we are all expected to reach the same line at the same time. So how to reach that goal? To reach the WHO goal to eliminate cervical cancer, we no longer discuss about the effectiveness of vaccine. We should discuss about the strategies to increase the HPV vaccination coverage, speed up cervical cancer screening for our friends. And we talk about the faster and even faster contact and how to reduce the inequity in special population. So a strategy for HPV vaccination. I think in December 2022, WHO gave the recommendation on HPV vaccination schedule. So we can consider one dose for girls and women who are under 20 years old. And we have many strong evidences to show the efficacy of single dose. So this is one of the studies published in 2022 show that the single dose HPV vaccination has 97.5% efficacy to prevent persistent HPV, cystic and aging infection. In terms of the cervical cancer screening, we are talking about HPV self-collection. This is recommended by WHO to contribute to eliminating cervical cancer by 2030 because HPV self-tandem is easy, convenient, cheap and private, convenient, cheap and private, and it's suitable for women in every country. And we have many, many strong evidence to support our self-collected samples. And we show that the HPV self-collected have the same similar accuracy in terms of the retention of CAN-2 blood or CAN-3 blood solution. So HPV self-collection is a way to go and it's a solution for rapid scale-up to achieving 70% cervical cancer screening. This is a slide about the cluster and even cluster concept. The cluster concept consists of offering concomitant screening and HPV vaccination to maximize the combined impact of both measures. And the even cluster is a slightly modified concept of cluster, which means focus on the age group that still transmitting in the infection. And this is a figure of the one assemble of the patient. We can see the three colors. The people in green group, women who are under than 20 years old, they are vaccinated and not a target of even cluster. In the blue group, with 40, older than 42 years old, they have basically reproductive number below one and have a low transmission of HPV infection. So the birth cohort age are 20, 22, 30 are vaccinated. They are a target of even cluster contain. That's the concept of even cluster. So we have many times that cervical cancer is a disease of inequity in the world and in the special population. We know that women living with HIV have six times more likely to develop cervical cancer. However, in a clinical process, we rarely see women living with HIV or people who are in sexual and gender minority come to here to have cervical cancer screening. So we should pay more attention to this special population. And currently, there are many ongoing researchers to answer many questions about, should we use the same strategy for vaccinated women and unvaccinated women? And should we treat the women who are HIV-infected by HIV-coronavirus vaccine? And should we use a human HPV vaccine after a seasonal procedure for CI? And so we are waiting for the results to accelerate cervical cancer control. And last but not least, in order to eliminate cervical cancer globally, we should have a strong collaboration in the world from the community, from the policy makers and many collaborations in community. In other words, to go together, we can make cervical cancer become a Z of the past. Thank you very much for your attention.

cervical cancer

preventable disease

World Health Organization

90-70-90 target

HPV vaccination coverage