Didactics-Integration of Molecular Classification into Managment of Patients with Endometrial Carcinoma

Integration of Molecular Classification into Managment of Patients with Endometrial Carcinoma

Video Transcription

Video Summary

The video content discusses new adjuvant radiation therapy and adjuvant chemotherapy as treatment options for cervical cancer patients. The speaker emphasizes the global shortage of radiation therapy resources and presents data from a phase 2 study in Mexico, which compared radiation therapy followed by brachytherapy to radiation therapy followed by radical hysterectomy. The study found no significant difference in overall or progression-free survival between the two approaches. The speaker also discusses a phase 3 study comparing surgery to brachytherapy, which found no improvement in survival outcomes with radical hysterectomy after chemotherapy. However, the study suggests that radical hysterectomy after external beam radiation therapy can be a feasible and safe treatment option, particularly when brachytherapy is not available. Additionally, the video presents findings from two studies on neoadjuvant chemotherapy, highlighting that chemo-radiation therapy may be more effective than neoadjuvant chemotherapy followed by surgery in stage 2B patients. However, for stage 1B2 patients, both approaches yield similar overall and progression-free survival rates. The speaker emphasizes the importance of monitoring patient response to neoadjuvant chemotherapy to inform treatment decisions.

Asset Subtitle

Philip Ip
December 2022

Keywords

adjuvant radiation therapy

adjuvant chemotherapy

cervical cancer

global shortage

neoadjuvant chemotherapy