Didactics-Interlace Study

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The Interlace study, published in October 2024, is a multi-center, randomized phase three trial examining treatment for locally advanced cervical cancer. It compares induction chemotherapy followed by standard chemoradiotherapy against standard chemoradiotherapy alone. The study found that the induction approach significantly improved five-year progression-free survival (72% vs. 64%) and overall survival (80% vs. 72%). Despite increased hematologic toxicity, particularly neutropenia, the method proved effective. The study highlights the importance of promptly starting chemoradiotherapy after induction. Future considerations include integrating checkpoint inhibitors in treatment protocols.

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Diego Aviles
December 2024

Keywords

cervical cancer

induction chemotherapy

chemoradiotherapy

progression-free survival

checkpoint inhibitors