Didactics-Systemic Therapies in Management of Carcinoma Cervix

Video Transcription

Video Summary

Dr. Amila Shilpakar discusses systemic therapies for the management of cervical carcinoma in this video. Cervical cancer is a significant public health issue globally, being the second most commonly diagnosed cancer and the third leading cause of cancer-related deaths among females, particularly in underdeveloped countries. Treatment usually involves a combination of surgery and radiation as local treatment, along with systemic therapies such as chemotherapy, targeted therapies, and immunotherapy. Chemotherapy can be used concurrently with radiation as part of definitive treatment, in the adjuvant setting, neoadjuvant setting, and in advanced metastatic or recurrent cases. The commonly used chemotherapy regime is weekly cisplatin with a dose of 40 milligrams per meter square, as it has shown similar outcomes to other combination regimes but with less toxicity. In advanced or metastatic cases, immunotherapy with pembrolizumab has shown promising results, especially in patients with a positive CPS score. Other drugs, such as semiplimab and tisotumab vedotin, are also being studied for their efficacy in recurrent or metastatic cervical cancer. The treatment landscape for cervical cancer is continually evolving, and palliative care plays a crucial role in improving patients' quality of life.

Asset Subtitle

Ramila Shilpakar
March 2023

Keywords

systemic therapies

cervical carcinoma

chemotherapy

targeted therapies

immunotherapy