HPV-independent vulvar neoplasia: an update on evolving diagnostic criteria-Recording

Video Transcription

Video Summary

Dr. Stephanie Scala gave a webinar on the evolving diagnostic criteria for HPV-independent vulvar neoplasia. She discussed the past terminology for vulvar neoplasia and the current evolving terminology for HPV-independent vulvar intraepithelial neoplasia (VIN). She talked about the histologic features that pathologists look for in the diagnosis of differentiated VIN, including basal atypia and elongated reedy ridges. She also highlighted the challenges in diagnosing HPV-independent VIN and the rationale for ordering immunohistochemical stains for P16 and P53. She explained that P53 staining can help distinguish between TP53 mutant and TP53 wild-type lesions, which have different prognostic implications. Dr. Scala emphasized the importance of accurate classification and collaboration between clinicians and pathologists. She also discussed potential challenges for pathologists in low-resource environments and the need for further research in this field. Overall, the webinar provided valuable insights into the evolving diagnostic criteria for HPV-independent vulvar neoplasia and highlighted the need for accurate classification and multidisciplinary care.

Keywords

HPV-independent vulvar neoplasia

terminology

VIN

histologic features

immunohistochemical stains

P16

P53

accurate classification

multidisciplinary care