HPV-independent vulvar neoplasia: an update on evolving diagnostic criteria

Video Transcription

Video Summary

In this webinar, Dr. Stephanie Scala discusses the evolving diagnostic criteria for HPV-independent vulvar neoplasia. She explains the past and current terminology for vulvar neoplasia and the histologic features that pathologists look for in the diagnosis of differentiated vulvar intraepithelial neoplasia (VIN). Dr. Scala emphasizes the challenges in diagnosing HPV-independent VIN and the rationale for ordering immunohistochemical stains for P16 and P53 when feasible. She also discusses other entities in the differential diagnosis of HPV-independent VIN and their impact on management decisions. Dr. Scala highlights the importance of multidisciplinary care, communication between clinicians and pathologists, and the use of immunohistochemistry in accurately classifying these lesions. She addresses common pitfalls, such as mistaking lichen simplex chronicus or infectious causes for neoplasia. Dr. Scala concludes by discussing the significance of P53 abnormalities in lichen sclerosis and potential methods for grading HPV-independent VIN. Overall, this webinar provides valuable insights into the evolving field of vulvar neoplasia diagnosis and management.

Keywords

webinar

HPV-independent vulvar neoplasia

histologic features

immunohistochemical stains

differential diagnosis

multidisciplinary care

communication

immunohistochemistry

neoplasia