In The Know-April 2021

April 2021
Pdf Summary
Ed's List for April 2021 includes abstracts from various journals related to gynecologic oncology. Here are the summaries of some of the articles featured in this month's list:<br /><br />1. Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors: This study investigates the use of DNPH1 inhibition in combination with PARP inhibitors to enhance the sensitivity of BRCA-deficient cells. The findings suggest that targeting DNPH1 could be a promising strategy for hypersensitization of BRCA-deficient cancers to PARP inhibitor therapy.<br /><br />2. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing: This study presents CRISPRoff, a single fusion protein that programs heritable epigenetic memory. The authors demonstrate that CRISPRoff can silence most genes and has a wide targeting window across gene promoters. This approach could have potential applications in gene silencing, genome-wide screens, and epigenetic inheritance exploration.<br /><br />3. Efficacy and Safety of First-line Single-Agent Carboplatin vs Carboplatin Plus Paclitaxel for Vulnerable Older Adult Women With Ovarian Cancer: This randomized clinical trial compares the feasibility, efficacy, and safety of single-agent carboplatin vs carboplatin plus paclitaxel in vulnerable older patients with ovarian cancer. The findings suggest that a conventional doublet regimen should be offered to all older adult patients with ovarian cancer, irrespective of vulnerability.<br /><br />4. High-risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels: This study explores the proteomic effects of FBXW7 mutations in high-risk endometrial cancers. The researchers identify L1 cell adhesion molecule (L1CAM) and transglutaminase 2 (TGM2) as potentially druggable proteins that are affected by FBXW7 mutations in endometrial cancers.<br /><br />5. Dysbiosis of the endometrial microbiota and its association with inflammatory cytokines in endometrial cancer: This study examines the composition of the endometrial microbiota and its association with inflammatory cytokines in endometrial cancer. The results suggest that dysbiosis of the endometrial microbiota and inflammatory cytokines are associated with each other in endometrial cancer patients.<br /><br />These summaries provide a brief overview of the findings and implications of the selected articles. Further details can be found in the full-text versions of the articles.
Keywords
DNPH1
BRCA-deficient cells
PARP inhibitors
CRISPRoff
gene silencing
carboplatin
paclitaxel
ovarian cancer
FBXW7 mutation
endometrial microbiota