In The Know-August 2021

August 2021
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This month's edition of Ed's List: In The Know features a range of articles on gynecologic oncology published from August 2021 to July 2021. Here are the highlights:<br /><br />1. "Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD)" - This study proposes a novel algorithm, GARD, to personalize radiation therapy dosage based on individual tumor genomics. It shows that GARD is associated with improved outcomes in various types of cancer.<br /><br />2. "Cell therapies in ovarian cancer" - This article explores the use of adoptive cell therapy, a personalized form of immunotherapy, in ovarian cancer treatment, including the transfer of tumor-infiltrating lymphocytes and engineered immune components.<br /><br />3. "Immune checkpoint inhibitors in ovarian cancer: where do we stand?" - This review discusses the use of immune checkpoint inhibitors in ovarian cancer treatment and explores strategies to enhance the therapeutic benefit of these agents.<br /><br />4. "Connections between prolactin and ovarian cancer" - This study investigates the effects of prolactin on ovarian cancer cells and explores the association between prolactin receptor expression and survival in ovarian cancer patients.<br /><br />5. "Chlamydia trachomatis, Pelvic Inflammatory Disease, and Epithelial Ovarian Cancer" - This article explores the interrelationship between chlamydia trachomatis infection, pelvic inflammatory disease, and epithelial ovarian cancer, highlighting the need for further research in this area.<br /><br />6. "Mutation- and methylation-profiles of ectopic and eutopic endometrial epithelium" - This study analyzes the genetic and epigenetic profiles of ectopic and eutopic endometrium in adenomyosis and peritoneal endometriosis, providing insights into the origins and evolution of these conditions.<br /><br />7. "Human papillomavirus vaccination history and diagnosis of cervical intraepithelial neoplasia grade ≥2 severe lesions among a cohort of women who underwent colposcopy" - This study examines the association between human papillomavirus (HPV) vaccination history and the risk of cervical intraepithelial neoplasia, finding no significant association between HPV vaccination and disease risk.<br /><br />8. "A machine learning approach to identify predictive molecular markers for cisplatin chemosensitivity following surgical resection in ovarian cancer" - This study uses machine learning to identify molecular markers that predict the response to cisplatin chemotherapy in ovarian cancer patients after surgery.<br /><br />9. "Incidence and Types of Human Papillomavirus Infections in Adolescent Girls and Young Women Immunized With the Human Papillomavirus Vaccine" - This cohort study investigates the impact of HPV vaccination on HPV infection rates in adolescent girls and young women, finding that vaccination is associated with lower rates of vaccine-related HPV types but higher rates of nonvaccine high-risk HPV types.<br /><br />10. "Novel Prognostic Score in Platinum Sensitive Relapsed Ovarian Cancer" - This study develops a prognostic score based on three factors that significantly predict progression-free survival in platinum-sensitive relapsed ovarian cancer.<br /><br />These articles provide insights into various aspects of gynecologic oncology and offer potential implications for the diagnosis, treatment, and prognosis of gynecologic cancers.
Keywords
gynecologic oncology
radiotherapy benefit
personalized radiation therapy
cell therapies
ovarian cancer
immune checkpoint inhibitors
prolactin and ovarian cancer
Chlamydia trachomatis
HPV vaccination
prognostic score