In The Know-August 2022

August 2022
Pdf Summary
This edition of Ed's List, titled "Gyn Onc Literature of Significance," provides a summary of several studies and trials related to gynecologic oncology. Here are some key highlights:<br /><br />1. "Novel Coronavirus Information": This article provides expert guidance and commentary on the coronavirus pandemic and its impact on cancer care.<br /><br />2. "Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk": This study investigates the potential link between regular aspirin use and the risk of ovarian cancer.<br /><br />3. "High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells": This research introduces Cluster-Wells, a new technology for isolating circulating tumor cell clusters, which can contribute to cancer research.<br /><br />4. "Evaluating Costs Associated With Genetic Counseling Among Commercially Insured US Patients With Cancer": This study examines the costs associated with genetic counseling and the factors influencing out-of-pocket costs for patients with cancer.<br /><br />5. "The Global Burden of Cancer Attributable to Risk Factors": This comprehensive analysis assesses the global burden of cancer caused by modifiable risk factors and provides valuable insights for cancer prevention strategies.<br /><br />6. "Plasma cfDNA Methylation Markers for the Detection and Prognosis of Ovarian Cancer": This study explores the potential of cell-free DNA methylation markers for early detection and prognosis of ovarian cancer.<br /><br />7. "Early-Stage Detection of Ovarian Cancer Based on Clinical Data Using Machine Learning Approaches": This research applies machine learning models and statistical methods to clinical data for the early diagnosis of ovarian cancer.<br /><br />8. "FDA Clears IND Application for AVB-001 in Relapsed/Refractory Ovarian Cancer": This article discusses the FDA's clearance of an IND application for AVB-001, a potential treatment for relapsed or refractory ovarian cancer.<br /><br />9. "Heterozygous BRCA1/2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents with Cancer": This study examines the prevalence and impact of pathogenic gene variants in children and adolescents with cancer.<br /><br />10. "Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics": This review explores various diagnostic methods and biomarkers for the screening and diagnosis of ovarian cancer.<br /><br />11. "Checkpoint Inhibitor Immunotherapy Diminishes Oocyte Number and Quality in Mice": This study investigates the impact of checkpoint inhibitor immunotherapy on ovarian function and fertility in mice.<br /><br />12. "Single-Cell RNA Sequencing Reveals the Tissue Architecture in Human High-Grade Serous Ovarian Cancer": This research uses single-cell RNA sequencing to study the tissue architecture of high-grade serous ovarian cancer and identify potential therapeutic targets.<br /><br />13. "BRCA Mutations Lead to XIAP Overexpression and Sensitize Ovarian Cancer to Inhibitor of Apoptosis Family Inhibitors": This study explores the role of BRCA mutations in XIAP overexpression and the sensitivity of ovarian cancer to inhibitor of apoptosis family inhibitors.<br /><br />14. "Effect of Apatinib Plus Pegylated Liposomal Doxorubicin vs Pegylated Liposomal Doxorubicin Alone on Platinum-Resistant Recurrent Ovarian Cancer": This randomized clinical trial evaluates the efficacy of apatinib combined with pegylated liposomal doxorubicin in patients with platinum-resistant recurrent ovarian cancer.<br /><br />15. "Real-life Data on Treatment and Outcomes in Advanced Ovarian Cancer": This observational study provides real-world data on the treatment strategies and outcomes in patients with advanced ovarian cancer.<br /><br />16. "Further Refining 2020 ESGO/ESTRO/ESP Molecular Risk Classes in Patients with Early-Stage Endometrial Cancer": This study aims to refine the molecular risk classes for early-stage endometrial cancer based on additional prognostic factors.<br /><br />17. "Tables of Contents for Gynecologic Oncology": This section provides the tables of contents for the latest issue of Gynecologic Oncology, which includes various research articles in the field.<br /><br />These summaries aim to provide a concise overview of the key findings and topics covered in each study.
Keywords
Gyn Onc Literature of Significance
Novel Coronavirus Information
Aspirin Use and Ovarian Cancer Risk
Circulating Tumor Cell Clusters
Genetic Counseling Costs
Global Burden of Cancer
Plasma cfDNA Methylation Markers
Machine Learning for Ovarian Cancer Detection
AVB-001 in Ovarian Cancer
BRCA1/2 Variants in Pediatric Cancer