In The Know-December 2020

December 2020
Pdf Summary
This summary provides a list of studies and their key findings in the field of gynecologic oncology. The studies cover various topics including the treatment outcomes of cervical cancer, neoadjuvant chemotherapy for endometrial cancer, maintenance therapy for ovarian cancer, and screening for ovarian and breast cancer in high-risk individuals. <br /><br />One study investigated the completion of radical hysterectomy in patients with cervical cancer and intraoperatively detected lymph node involvement and found that it did not improve survival outcomes. Another study focused on neoadjuvant chemotherapy for metastatic endometrial cancer and found that it was associated with improved overall survival. <br /><br />A study on maintenance therapy for ovarian cancer evaluated different treatment strategies and found that none of the maintenance regimens were cost-effective, except for olaparib when the price was reduced by half. <br /><br />Two studies explored the use of different screening methods for early detection of ovarian cancer. One study found that high-risk human papillomavirus (hrHPV) testing was a more effective screening method compared to cytology or visual inspection with acetic acid and Lugol iodine. The other study investigated the prevalence of abnormal cervical cancer screening outcomes and found that 12.38% of women had abnormal Pap test results and 12.85% had abnormal HPV test results. <br /><br />Other studies focused on specific genes related to ovarian and breast cancer risk. One study found that pathogenic variants in the RAD51C and RAD51D genes were associated with increased risks of tubo-ovarian carcinoma and breast cancer. Another study investigated the role of BRCA1 promoter methylation in ovarian cancer and found that it did not have a significant impact on clinical outcomes. <br /><br />Overall, these studies provide valuable insights into the management and treatment of gynecologic cancers and contribute to our understanding of risk factors and screening methods.
Keywords
gynecologic oncology
cervical cancer
neoadjuvant chemotherapy
maintenance therapy
ovarian cancer
screening methods
high-risk individuals
breast cancer
genes
clinical outcomes