In The Know-January 2023

January 2023

Pdf Summary

In this edition of Ed's List: In The Know, several significant studies in the field of gynecologic oncology are summarized. <br /><br />The first study examines the risk of endometrial polyps, hyperplasia, carcinoma, and uterine cancer in premenopausal women with breast cancer who have been treated with tamoxifen. The study found that tamoxifen treatment is associated with an increased risk of these conditions.<br /><br />Another study explores the association between US drug prices and efficacy measures for oncology drugs approved by the US Food and Drug Administration. The study found that there is no significant correlation between higher drug prices and improved efficacy measures.<br /><br />A study focused on high-grade serous ovarian carcinoma (HGSOC) discovered that LINE-1 ORF1p expression is detectable in fallopian tube (FT) epithelial precursors of HGSOC, suggesting that it may be an early event in HGSOC development. In addition, treatment with DNA methyltransferase inhibitors led to robust expression and release of ORF1p in FT cells, validating the regulatory role of DNA methylation in LINE-1 repression.<br /><br />Other studies examined topics such as predicting complete cytoreduction in women with advanced ovarian cancer, the stage at diagnosis and survival of women with cervical cancer, the association between lifetime ovulatory years and risk of epithelial ovarian cancer, and risk prediction models for endometrial cancer.<br /><br />Furthermore, a study investigated the use of pafolacianine injection for intraoperative imaging of folate receptor-positive ovarian cancer. The study confirmed that pafolacianine can improve the detection of additional cancer lesions during surgery.<br /><br />Finally, several studies focused on fracture risk among cancer survivors. Some studies found that older cancer survivors, especially those who were more recently diagnosed or who had chemotherapy, have a higher risk of pelvic and vertebral fractures. Strategies to reduce fracture risk in cancer survivors include physical activity and smoking cessation programs.<br /><br />These studies contribute to the understanding of gynecologic oncology and provide valuable insights for clinical practice and further research.

Keywords

gynecologic oncology

endometrial polyps

tamoxifen treatment

US drug prices

efficacy measures

high-grade serous ovarian carcinoma

DNA methylation

complete cytoreduction

pafolacianine injection

fracture risk