In The Know-July 2020

July 2020

Pdf Summary

This document provides a summary of significant findings in the field of gynecologic oncology from July 2020 to June 2020. <br /><br />One study found that CRISPR gene-editing technology can lead to unintended consequences and large-scale disruptions in DNA when used in embryos, which has implications for cancer treatments.<br /><br />Another study examined the risk of vulvar squamous cell carcinoma in patients with high-grade vulvar intraepithelial neoplasia (VIN) and found that the risk is lower in high-grade squamous intraepithelial lesion (HSIL) compared to differentiated VIN (dVIN).<br /><br />A study on cervical adenocarcinomas found that some cases that were previously diagnosed as cervical adenocarcinoma were actually endometrial, serous, clear-cell, or gastric-type adenocarcinomas. This highlights the importance of accurate diagnosis and classification.<br /><br />The use of primary human papillomavirus (HPV) testing was recommended as the preferred screening strategy for cervical cancer, with the recommended age to start screening being 25 years.<br /><br />A study on patients with synchronous endometrial and ovarian cancers found that these cases are actually metastatic endometrial cancer, with favorable clinical outcomes.<br /><br />Other studies explored topics such as the use of minimally invasive surgery for early-stage ovarian cancer, the association between endometriosis and ovarian cancer, the clearance of HPV after treatment for cervical cancer, and the molecular profiling of ovarian and endometrial cancers.<br /><br />Overall, these findings contribute to our understanding of gynecologic oncology and can potentially impact clinical practice and treatment approaches.

Keywords

gynecologic oncology

CRISPR gene-editing technology

vulvar squamous cell carcinoma

cervical adenocarcinomas

primary human papillomavirus testing

synchronous endometrial and ovarian cancers

minimally invasive surgery

endometriosis

HPV clearance

molecular profiling