In The Know-July 2023

July 2023

Pdf Summary

The July edition of Ed's List highlights several significant findings in the field of gynecologic oncology. One study explores the impact of dietary quality on genital oncogenic HPV infection in women, while another focuses on the effect of host obesity on the immune microenvironment of ovarian tumors. Additional studies delve into the role of anti-Müllerian hormone in regulating cancer-associated mesothelial cells, assess interactions in risk stratification models for ovarian cancer, and identify high-grade serous ovarian carcinoma-specific extracellular vesicles. Other research investigates a multicancer early detection test in symptomatic patients, unveils the epigenomic mechanisms of acquired platinum resistance in ovarian cancer, and examines the prevalence and landscape of germline variants in patients with gynecologic cancers. Furthermore, a study evaluates the efficacy of niraparib maintenance therapy in newly diagnosed advanced ovarian cancer, while another investigates chemotherapy responses in low-grade serous ovarian carcinoma. Lastly, two studies focus on microsatellite instability in noncolorectal and nonendometrial malignancies in patients with Lynch syndrome, as well as kidney function in patients treated with poly (ADP-ribose) polymerase (PARP) inhibitors for ovarian cancer.

Keywords

gynecologic oncology

HPV infection

ovarian tumors

immune microenvironment

ovarian cancer

extracellular vesicles

germline variants

advanced ovarian cancer

chemotherapy responses

Lynch syndrome