In The Know-May 2021

May 2021

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Ed's List for May 2021 provides a compilation of abstracts related to gynecologic oncology from various scholarly journals. Some of the key findings from the included studies are:<br /><br />1. A study analyzed the response and resistance to the PARP inhibitor rucaparib for recurrent ovarian cancer treatment. The analysis found that RAD51C and RAD51D mutations, as well as high-level BRCA1 promoter methylation, predicted response to rucaparib. Genomic scars associated with homologous recombination deficiency were also predictive of rucaparib response in platinum-sensitive disease.<br /><br />2. Another study investigated genetic alterations in epithelial ovarian cancer. The analysis identified various genetic alterations and their therapeutic implications across different histologic types of ovarian cancer. The findings provided insights into the personalization of therapy and biomarker analysis for clinical studies.<br /><br />3. A study compared the dose-dense regimen of paclitaxel and carboplatin with the standard 3-weekly regimen in the first-line treatment of ovarian cancer. The analysis showed that dose-dense treatment was associated with longer progression-free survival compared to the standard regimen.<br /><br />4. Researchers evaluated the use of genetic navigation to increase the uptake of genetic testing for Lynch syndrome in patients with endometrial and ovarian cancer. The study found that implementing a genetic navigation program significantly increased the rate of genetic assessment in patients at risk for Lynch syndrome.<br /><br />5. A study assessed the use of hyperthermic intraperitoneal chemotherapy (HIPEC) with carboplatin for recurrent ovarian cancer during secondary cytoreductive surgery. The analysis showed that HIPEC with carboplatin was well tolerated but did not result in superior clinical outcomes compared to standard treatment.<br /><br />These studies highlight the importance of genetic testing, personalized therapy, and innovative treatment approaches in the field of gynecologic oncology.

Keywords

gynecologic oncology

PARP inhibitor rucaparib

recurrent ovarian cancer

RAD51C

RAD51D mutations

BRCA1 promoter methylation

epithelial ovarian cancer

genetic alterations

dose-dense regimen

paclitaxel