Journal Club: What happens after menopause? (WHAM): A prospective controlled study of vasomotor symptoms and menopause-related quality of life 24 months after premenopausal risk-reducing salpingo-ooph-Recording

Video Transcription

Video Summary

The IGCS Education 360 Journal Club video presented by Anissa Mburu focused on a study known as WAM (What Happens After Menopause), examining the effects of premenopausal risk-reducing salpingo-oophorectomy on vasomotor symptoms and menopause-related quality of life. The study, led by Dr. Sarah Price, involved 200 women, some of whom underwent oophorectomy due to high ovarian cancer risk, primarily due to BRCA1 or 2 mutations. It aimed to measure the trajectory and severity of symptoms over 24 months, focusing on the impact of menopausal hormonal therapy. Key findings included a significant increase in vasomotor symptoms shortly after surgery, which stabilized thereafter, and a decrease in menopausal quality of life related mainly to sexual and vasomotor symptoms. Hormonal therapy mitigated but did not eliminate symptoms, highlighting varied individual experiences. The discussion emphasized the potential for diverse physiological responses, the need for further research in more ethnically varied populations, and the importance of long-term data to fully understand the impact of surgical menopause on health outcomes. The Journal Club also included future research plans for a ten-year follow-up study to assess long-term health impacts, including cancer incidence and cardiovascular events.

Keywords

menopause

salpingo-oophorectomy

vasomotor symptoms

BRCA mutations

hormonal therapy

surgical menopause

long-term health outcomes