Pragmatic Clinical Trial Resources-Lessons from other Networks/Situations: SONATA study

Video Transcription

Video Summary

Sudha Sundar explains how real-world data can inform gynecologic cancer practice by using routinely collected sources such as electronic health records, cancer registries, and hospital datasets. She contrasts real-world evidence, which measures effectiveness in everyday practice, with randomized trials, which mainly measure efficacy in selected patients. <br /><br />She describes two practice-changing UK studies. First, her population-based work on maximal cytoreductive surgery for advanced ovarian cancer showed that centers offering high-complexity surgery had better survival at a geographical population level, without harming quality of life. This supported UK guidance changes and improved training, governance, and national complication reporting. <br /><br />Second, she discusses the National Ovarian Cancer Audit, which publicly reports center-level ovarian cancer outcomes to drive improvement. <br /><br />Finally, she introduces the SONATA study, which uses anonymized linked NHS data to compare ROMA with CA125 for early ovarian cancer diagnosis in women with symptoms. She concludes that well-designed real-world studies can answer important questions quickly, at scale, and with less bias.

Asset Subtitle

SONATA study by Sudha Sundar

Keywords

real-world evidence

gynecologic cancer

ovarian cancer

electronic health records

randomized trials