Pragmatic Clinical Trial Resources-Pragmatic Clinical Trials in Resource adapted settings: Implementation and novel designs

Pragmatic Clinical Trials in Resource adapted settings: Implementation and novel designs

Video Transcription

Video Summary

The webinar introduced Professor Asima Mukhopadhyay, who spoke about pragmatic clinical trials in resource-adapted settings and why they matter for gynecologic cancer research. She explained that pragmatic trials are designed to be closer to real-world practice, with more flexible eligibility, recruitment, follow-up, and outcomes, while still maintaining scientific rigor. Key themes included inclusivity, cost-efficiency, patient-centered outcomes, and implementation science.<br /><br />Professor Mukhopadhyay highlighted the role of GCIG and the Cervical Cancer Research Network in expanding global collaboration beyond high-resource centers, especially to low- and middle-income countries. She emphasized that many important clinical questions in gynecologic oncology—such as de-escalation strategies, toxicity reduction, and feasibility of care—may be better addressed through pragmatic or hybrid trial designs rather than large traditional RCTs.<br /><br />She also discussed innovative methods such as master protocols, registry-based trials, adaptive designs, minimal data sets, and mixed-method approaches. A major message was that trials in low-resource settings must be carefully planned, collaborative, and locally relevant, while also building research capacity and involving young investigators. The session ended with a Q&A focused on trial design, generalizability, collaboration, and how to start pragmatic research groups.

Asset Subtitle

Presented by Prof. Asima Mukhopadhyay
Recorded May 7, 2026

Keywords

pragmatic clinical trials

gynecologic cancer research

resource-adapted settings

implementation science

global collaboration

low- and middle-income countries

master protocols

adaptive trial designs

cervical cancer research network