Pragmatic Clinical Trial Resources-Using Real World Data

Video Transcription

Video Summary

Austin Miller explains real-world data (RWD) as routinely collected health care information used to bridge gaps between clinical trials and everyday patient care. He emphasizes that randomized trials provide internally valid evidence, while RWD helps assess generalizability, safety, epidemiology, and treatment use. The talk covers RWD sources, the importance of standardized data structures, and planning steps: define the question, choose an appropriate observational design, and write a detailed statistical analysis plan. He also highlights privacy protections, bias/confounding concerns, and methods like causal modeling, instrumental variables, and propensity scores to turn RWD into real-world evidence and insights.

Asset Subtitle

Using Real World Data by Austin Miller

Keywords

real-world data

clinical trials

observational study design

propensity scores

causal modeling