IGCS and Eisai welcomes you to view Personalized Management of Advanced or Recurrent Endometrial Cancers: Navigating pMMR, dMMR Subtypes, or Molecular Classifications Industry Supported Symposium presented at the IGCS 2024 Annual Global Meeting in Dublin, Ireland. This course offers an in-depth exploration of personalized treatment approaches for endometrial cancers, focusing on proficient mismatch repair (pMMR), deficient mismatch repair (dMMR) diseases and molecular classification in the recurrent setting. Through case-based studies, and analysis of clinical data, participants will gain insights into tailored treatment strategies, including the use of immune checkpoint inhibitors, chemotherapy, and targeted therapies. The course also examines the challenges of managing treatment toxicities and poor tolerance in pMMR patients, utilizing evidence from post-adjuvant sub-analyses to inform decision making and optimize patient outcomes.
New Presentation as of September 2025!
Treatment Sequencing in pMMR Endometrial Cancers: Insights from Adjuvant to Targeted Therapies (1st line metastatic)
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Domenica Lorusso, MD, PhD, is Director of Gynaecological Oncology Unit at Humanitas Hospital San Pio X, Milan, and Full Professor of Obstetrics and Gynaecology, Humanitas University, Rozzano (MI). Prof Lorusso has been involved in gynecological oncology research for more than 25 years and has conducted or participated in approximately 250 phase I-IV clinical trials in gynecological malignancies. At present she is Principal Investigators of more than 60 studies. Prof Lorusso is responsible of the Clinical Trials Committee of the MITO (Multicenter Italian Trials in Ovarian Cancer and Gynaecological Malignancies) Group, which includes more than 150 Italian centers involved in gynecological oncology research. She is member of Board of Directors of Gynaecological Cancer Intergroup including 23 international research groups involved into the promotion and conduction of high-quality clinical trials to improve outcomes for women with gynecological cancers. Prof Lorusso is also active member of ENGOT (European Network of Gynaecological Oncological Trial groups) an international organization which coordinates and promotes clinical trials within Europe for patients with gynecological cancers where she chairs the Gynecological cancer Academy. She is member of Board of Director of European Society of Gynecology Oncology (ESGO). She has also co-authored about 300 international oncology publications. She is author of national and international guidelines on treatment of ovarian, cervical and endometrial cancer. Dr Lorusso’s key goals are to ensure best treatment to all patients and promote the clinical research, international trial collaborations and educations.
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Second Presentation: Therapeutic Strategies for dMMR/pMMR Endometrial Cancers: Insights from Case Based Analysis (2nd line metastatic)
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Dr. Angélica Nogueira-Rodrigues graduated in Medicine at the Federal University of Minas Gerais (UFMG), Brazil. She completed medical residency in Internal Medicine at UFMG, and in Oncology at the Brazilian National Cancer Institute (INCA). She pursued a PhD in Oncology at INCA and a Post-Doctoral fellowship in global oncology at Harvard University. She is the President-elect of the Brazilian Gynecologic Oncology Group (SBOC); Strategy Director Brazilian Group of Gynecologic Cancer; Chair of Gynecology in Latin America Cooperative Oncology Group; Researcher and professor at UFMG; Oncologist DOM and leader OC Mulher Oncoclínicas.
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First Presentation: pMMR vs dMMR Disease, Molecular Considerations in the Recurrent and First Line Setting
Presenter: John Chan, MD, California Pacific Medical Center, Sutter Health, USA
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Dr. John K. Chan is the Division Director of Gynecologic Oncology and the Denise & Prentis Cobb Hale Endowed Chair at the California Pacific Medical Center and serves as a Principal Investigator Lead of the Sutter Cancer Research Consortium. He is an Adjunct Clinical Professor at University of California San Francisco, Stanford University and Dartmouth School of Medicine. Dr. Chan earned his medical degree at University of California, Los Angeles and completed his Fex Rutledge fellowship at MD Anderson Cancer Center and gynecologic oncology fellowship at University of California Irvine. He has conducted numerous gynecologic cancer clinical trials and has received grants and awards, including those from the National Cancer Institute, the Ovarian Cancer Research Foundation, Gynecologic Cancer Foundation, and the Gynecologic Oncology Group. Dr. Chan has authored and co-authored over 220 peer-reviewed journals including New England Journal of Medicine, Journal of the American Medical Association, Lancet Oncology, Journal of Clinical Oncology, Gynecologic Oncology and International Journal of Gynecologic Cancers. He is also the co-author of five textbooks in the field of Gynecologic Oncology. Academically, he has received numerous outstanding medical student and resident teaching awards from Stanford University and University of California School of Medicine at Irvine and San Francisco. Clinically, he is consistently selected as the Best Doctor Award as recognized by the U.S. News and World Report, Castle Connolly Medical Ltd, and San Francisco Magazine.
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