Didactics-Alternatives to the standard when brachetherapy not available

Alternatives to the standard when brachetherapy not available_ Anuja Jhingran April 2020

Video Transcription

Video Summary

The video summarizes the use of new adjuvant radiation therapy and chemotherapy in treating cervical cancer patients. The lack of radiation therapy resources globally is highlighted. A phase 2 study in Mexico compared radiation therapy followed by brachytherapy versus surgery. No difference in overall survival or progression-free survival was found, although surgery had higher hydronephrosis rates, and brachytherapy had higher rates of proctitis and cystitis. A phase 3 study is being conducted. Neoadjuvant chemotherapy was also compared to chemo radiation. A study in India showed better disease-free survival with chemo radiation, especially in stage 2B patients. Another study found no difference in overall survival but better progression-free survival with chemo radiation. Responders to neoadjuvant chemotherapy had better outcomes. For stage 2B patients, chemo radiation is preferred, while for stage 1B to 2A, neoadjuvant chemotherapy followed by surgery is considered equivalent. Response to chemotherapy should be monitored. The video emphasizes the importance of follow-up and discussions on treatment options based on resources and patient response. No credits were mentioned in the video.

Keywords

adjuvant radiation therapy

chemotherapy

cervical cancer

global radiation therapy resources

neoadjuvant chemotherapy