Didactics-Endometriosis and Ovarian Cancer

Video Transcription

Video Summary

The speaker, Professor Nidjar, discusses the relationship between endometriosis and the risk of ovarian cancer in a presentation. He explains that endometriosis is a common chronic inflammatory estrogen-dependent disease in women, which can lead to various symptoms such as chronic pelvic pain, infertility, abnormal uterine bleeding, and organ dysfunction. He highlights the risk of malignant transformation in endometriosis, specifically the increased risk of ovarian cancer. Professor Nidjar references epidemiological studies showing positive associations between endometriosis and ovarian cancer, with a higher risk for certain types of ovarian cancer like clear cell carcinoma and endometrioid carcinoma. He delves into the pathogenesis of this malignant transformation, which involves somatic genetic mutations, inflammation, and hormonal factors, such as increased estrogen levels. He also discusses the clinical implications of this data, including the risk factors for malignant transformation and the need for early diagnosis. In terms of prevention, he suggests surgical removal of endometriosis lesions and the use of hormonal suppressive therapy to decrease the risk. He also discusses the importance of monitoring endometriomas for potential malignant transformation, and highlights the need for individualized surgical approaches based on patient risk factors and desires. Finally, he mentions the potential for future advancements in screening and treatment based on molecular profiling. No specific video or credits are mentioned.

Asset Subtitle

Farr Nezhat
October 2021

Keywords

endometriosis

ovarian cancer

chronic inflammatory disease

malignant transformation

risk factors

surgical removal

hormonal suppressive therapy