Didactics-Gestational Trophoblastic Neoplasia

Video Transcription

Video Summary

In this video, the speaker discusses gestational trophoblastic neoplasia (GTN), a group of trophoblastic tissues that can invade locally or metastasize. The lungs are the most common site of metastasis, but distant sites such as the brain and liver can also be affected. The cure rate for low-risk GTN is very high, with almost 100% remission rates reported in some literature. High-risk patients have a cure rate of over 95%, thanks to the use of beta HCG as a marker and diagnostic tests for treatment surveillance. The speaker explains that in their country, they use a combined scoring system, which categorizes the patient as high-risk, but they would start stage one patients with single-agent chemotherapy. Stage two or three patients with low risk scores may also receive single-agent chemotherapy, while those with high risk scores receive multi-agent chemotherapy. The speaker also discusses different combinations of chemotherapy drugs and treatment options for salvage therapy. They share their experience and outcomes from their institution, including surgical interventions and adjuvant therapies. The speaker concludes by sharing two cases of GTN patients and highlighting the importance of managing adverse effects of chemotherapy and complications.

Asset Subtitle

Maria Stephanie Fay S. Cagayan
July 2021

Keywords

gestational trophoblastic neoplasia

trophoblastic tissues

metastasis

cure rate

beta HCG

chemotherapy