Didactics-Granulosa cell tumors of the Ovary

Video Transcription

Video Summary

In this video, the speaker discusses granulosa cell tumors, which represent the largest portion of the 7% of ovarian cancers that are sex cord stromal tumors. These tumors arise from sex cord stromal tumors and their precursors, and can present with symptoms such as pelvic mass, pain, bloating, and abnormal uterine bleeding. The speaker emphasizes that surgery is the primary treatment for these tumors, with the goal of achieving maximal cytoreduction and no visible disease. Fertility-sparing surgery is important for young patients, and minimally invasive surgery can be used in certain cases. The speaker also mentions that lymphadenectomy is not necessary for staging granulosa cell tumor patients. In terms of adjuvant therapy, the speaker discusses the use of platinum-based chemotherapy, which has shown activity in granulosa cell tumors. Other treatment options include taxanes and the combination of bleomycin, etoposide, and cisplatin. The speaker also highlights the potential use of bevacizumab, hormonal therapy, and radiation therapy. Surveillance methods for these tumors include monitoring inhibins, anti-malarian hormone, CA-125, pelvic examination, and imaging. The speaker concludes by stating that both paclitaxel and carboplatin and BEP can be used as chemotherapy options, with paclitaxel and carboplatin having a more favorable side effect profile.

Asset Subtitle

Jubilee Brown
October 2020

Keywords

granulosa cell tumors

sex cord stromal tumors

ovarian cancers

surgery

chemotherapy