Didactics-Indications and contraindictions for radiation therapy for advanced LACC, when a tumor grows in the bladder or rectum. Is Bleeding a contraindication for radiation therapy?

Indications and contraindictions for radiation therapy for advanced LACC, when a tumor grows in the bladder or rectum. Is Bleeding a contraindication for radiation therapy?

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Video Transcription

Video Summary

In this video, the speaker discusses the role of radiotherapy in the treatment of locally advanced cervical cancer. They explain that the standard treatment for this stage of the disease is a combination of external beam radiotherapy with concurrent cisplatin chemotherapy followed by brachytherapy. The speaker emphasizes the importance of image-guided brachytherapy and its ability to deliver higher doses of radiation to the cancer while minimizing damage to surrounding healthy organs. They also mention ongoing trials investigating the benefits of adjuvant or neoadjuvant systemic therapy. The speaker then presents data from various studies that highlight the prognostic factors and outcomes for patients with stage IVa disease, including bladder and rectal involvement, performance status, tumor size, and nodal involvement. The risk of vesicovaginal fistula formation is also discussed, with specific factors such as tumor necrosis and bladder wall involvement identified as prognostic indicators. The video concludes by addressing the indications and contraindications for radiotherapy, including considerations for curative or palliative intent, comorbidities, and access to brachytherapy. The importance of a multidisciplinary team in the evaluation and treatment decision-making process is emphasized.

Asset Subtitle

Remi A. Nout
July 2020

Keywords

radiotherapy

locally advanced cervical cancer

brachytherapy

prognostic factors

adjuvant systemic therapy

multidisciplinary team