Didactics-The Genesis of Modern Uterine Cancer Treatment

Video Transcription

Video Summary

In this video, Dr. Jubilee Brown, a professor of gynecologic oncology, discusses the evolution of uterine cancer treatment. She highlights the shift from open surgery to minimally invasive surgery and the development of medical therapies. Dr. Brown explains that in the past, uterine cancer treatment involved open surgery with radical dissections and limited medical options. However, with advancements in laparoscopic surgery, patients now benefit from shorter hospital stays and less invasive procedures. She also discusses the importance of lymphatic mapping, which involves injecting dye to identify and remove sentinel lymph nodes for more accurate staging and reduced surgical morbidity. Dr. Brown emphasizes the significance of genomic testing in understanding tumor characteristics and determining appropriate treatment options. Specifically, she highlights the use of immunotherapy, such as pembrolizumab and distarlamab, for patients with deficient mismatch repair genes, showing high response rates and long-lasting responses. Dr. Brown concludes by explaining how these advancements have allowed for less aggressive surgery, decreased morbidity, and improved outcomes for patients with uterine cancer.

Asset Subtitle

Jubilee Brown

Keywords

uterine cancer treatment

minimally invasive surgery

medical therapies

laparoscopic surgery

lymphatic mapping

genomic testing

immunotherapy